ILM-BLUE®

High purification - minimum 97% purity

Features

ILM-Blue® is a dye to stain the ILM in vitreoretinal surgery.

By injecting ILM-Blue® in the vitreous cavity the ILM 
will be clearly stained and easily distinguished from the underlying, unstained retina and can be removed selectively.

Due to an integrated carrier 4% PEG solution, ILM-Blue® can be injected in a BSS filled eye and sinks immediately as a cohesive ball to the fundus of the eye and only stains the targeted tissue without diffusion throughout the whole globe.

 

Effective ILM staining due to high purification - minimum 97% purity
ILM-BLUE®: Posterior Dye for staining the ILM consists of: 

BBG 0,025% + 4% PEG

Highly purified BBG - minimum 97% purity

 

Advanced injection characteristics due to "carrier" 4% PEG solution
Creates better injection characteristics under BSS.
Sinks immediately to posterior pole as a cohesive ball. 
Stains only target tissue and no diffusion throughout the eye.

 

Specifications ILM-BLUE® 
Composition of one 0.5ml syringe

Brilliant Blue G: 0.125 mg

PEG: 4% PEG 3350

Concentration: 0.25 g/l

pH-value: 7.3 - 7.6

Osmolality: 301 - 369 mOsm/kg H2O

Purity & safety

LM-Blue® is produced with highly purified BBG at a drug substance level.

Safety tests

Toxicity tests on ARPE-19 human retinal pigment epithelium cells showed an advantageous safety profile of ILM-Blue®. Increased purity of the dyes as well as the addition of PEG3350 results in even safer products. Safety testing was complemented by electron microscopy ultrastructural analysis and in vitro cytotoxicity tests according to ISO-10993.

Patent protected

USA (6,696,430B1, 6,372,449, 20080090914A1), Australia (75731 8), Japan (4200222), Europe (EP 1 819 366, B1). Technology licensed from AQUMEN, Japan.

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