• MembraneBlue-Dual® is a dye to stain both the ILM as well as the ERM and PVR membrane, without compromising the staining effect within one injection.
• By injecting MembraneBlue-Dual® in the vitreous cavity the membrane will be clearly stained and easily distinguished
  from the underlying, unstained retina and can be removed selectively.
• Extensive tests proved that MembraneBlue-Dual® is a 100% stable mix and stains the ILM at the same level as ILM-Blue® and stains the ERM and PVR at a higher level than the classic MembraneBlue.
• Due to a new integrated carrier 4% PEG solution,
  MembraneBlue-Dual® can be injected in a BSS filled eye
  and sinks imme-diately as a cohesive ball to the fundus of
  the eye and only stains the targeted tissue without
  diffusion throughout the whole globe.
  
  
  
  

• Combination of TrypanBlue 0,15%
  + BBG 0,025% + 4% PEG
• Highly purified TB + BBG up to 97%

Best injection characteristics
due to new "carrier" 4% PEG solution
Creates better injection characteristics under BSS.
Sinks immediately to posterior pole as a cohesive ball.
Stains only target tissue and no diffusion throughout the eye.

Specifications MEMBRANEBLUE-DUAL®
Composition of one 0.5ml syringe

• 0.125 mg
• 0.75 mg
• PEG
• Density kg/l

Concentration:
pH-value:
Osmolality:

• Brilliant Blue G
• Trypan Blue
• 4% PEG 3350
• 1,01

1.75 g/l
7.3 - 7.6
338 mOsm/kg H2O

• MembraneBlue-Dual®is produced according to Current
  Good Manufacturing Practice (CGMP)
• MembraneBlue-Dual® is produced with highly purified
  BBG + Trypanblue at a drug substance level.

Safety tests
Toxicity tests on ARPE-19 human retinal pigment epithelium
cells showed an advantageous safety profile of the new
products MembraneBlue-Dual®.

Increased purity of the dyes as well as the addition
of PEG3350 results in even safer products.

Safety testing was complemented by electron microscopy
ultrastructural analysis and in vitro cytotoxicity tests
according to ISO-10993.